https://www.cohenlaboratory.org/research-topics-1 daily 0.75 2016-05-19 https://www.cohenlaboratory.org/research-topics-1/2016/5/19/them1 monthly 0.5 2016-05-19 https://images.squarespace-cdn.com/content/v1/5722360f27d4bd88f0e1ab06/1463681332104-5BXCLV4GAXOG033HD4DP/Them1 Research Topics - Them1 https://www.cohenlaboratory.org/research-topics-1/2016/5/19/pc-tp-1 monthly 0.5 2016-05-19 https://images.squarespace-cdn.com/content/v1/5722360f27d4bd88f0e1ab06/1463681237818-D4GIEV8PKAF8SHZ2EYOR/PC-TP Research Topics - PC-TP https://www.cohenlaboratory.org/new-gallery-1 daily 0.75 2016-05-19 https://www.cohenlaboratory.org/research-topics daily 0.75 2016-05-19 https://images.squarespace-cdn.com/content/v1/5722360f27d4bd88f0e1ab06/1463679613955-GRD31X7TRIV2RV0J4YF0/PC-TP.jpg Research Topics - PC-TP Phosphatidylcholine transfer protein (PC-TP, synonym StARD2) binds phosphatidylcholines, and catalyzes their intermembrane transfer and exchange in vitro. The structure of PC-TP comprises a hydrophobic pocket and a well-defined head group binding site, and its gene expression is regulated by peroxisome proliferator activated receptor-alpha. Recent studies have revealed key regulatory roles for PC-TP in lipid and glucose metabolism. Notably, Pctp(-/-) mice are sensitized to the action of insulin, and exhibit more efficient brown fat-mediated thermogenesis. PC-TP appears to limit access of fatty acids to mitochondria by stimulating the activity of thioesterase superfamily member 2, a newly characterized long-chain fatty acyl-coenzyme A thioesterase. Because PC-TP discriminates between phosphatidylcholines within lipid bilayers, it might function as a sensor that links metabolic regulation to membrane composition. https://images.squarespace-cdn.com/content/v1/5722360f27d4bd88f0e1ab06/1463679613955-GRD31X7TRIV2RV0J4YF0/PC-TP.jpg Research Topics - PC-TP Phosphatidylcholine transfer protein (PC-TP, synonym StARD2) binds phosphatidylcholines, and catalyzes their intermembrane transfer and exchange in vitro. The structure of PC-TP comprises a hydrophobic pocket and a well-defined head group binding site, and its gene expression is regulated by peroxisome proliferator activated receptor-alpha. Recent studies have revealed key regulatory roles for PC-TP in lipid and glucose metabolism. Notably, Pctp(-/-) mice are sensitized to the action of insulin, and exhibit more efficient brown fat-mediated thermogenesis. PC-TP appears to limit access of fatty acids to mitochondria by stimulating the activity of thioesterase superfamily member 2, a newly characterized long-chain fatty acyl-coenzyme A thioesterase. Because PC-TP discriminates between phosphatidylcholines within lipid bilayers, it might function as a sensor that links metabolic regulation to membrane composition. https://images.squarespace-cdn.com/content/v1/5722360f27d4bd88f0e1ab06/1463679876382-9AT1HRCOXF8LQBYAKW7Y/Them1-Okada.jpg Research Topics - Them1 Thioesterase superfamily member 1 (Them1), a BAT-enriched long chain fatty acyl-CoA thioesterase, is upregulated by cold and downregulated by warm ambient temperatures. Them1 (-/-) mice exhibit increased energy expenditure and resistance to diet-induced obesity and diabetes, but the mechanistic contribution of Them1 to the regulation of cold thermogenesis remains unknown. Them1 may act as a break on uncontrolled heat production and limit the extent of energy expenditure. Pharmacologic inhibition of Them1 could provide a targeted strategy for the management of metabolic disorders via activation of brown fat. https://www.cohenlaboratory.org/david-cohen daily 0.75 2025-07-01 https://images.squarespace-cdn.com/content/v1/5722360f27d4bd88f0e1ab06/2f59d5e2-51ba-4e9d-a9c5-095edbb40fe6/CohenPhoto.png David E. 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