Crystal Structure of Human Phosphatidylcholine Transfer Protein in Complex with Dilinoleoylphosphatidylcholine

The Laboratory of Dr. David E. Cohen forms part of the Division of Gastroenterology, Hepatology and Endoscopy at Brigham and Women’s Hospital.

Our research centers on the mechanisms whereby hydrophobic lipid molecules regulate nutrient metabolism and energy homeostasis. We seek to identify new molecular targets that could be leveraged in the management of obesity and its common metabolic complications, including non-alcoholic fatty liver disease and type 2 diabetes.